Atypical lymphocytosis is present in approximately 75% of patients infected with mononucleosis.The laboratory hallmark of the disease is the presence of atypical lymphocytes (a type of mononuclear cell) on the peripheral blood smear.The presence of atypical lymphocytes (often recorded by automated blood analyser machines as an increase in the monocycte count) is characteristic of EBV infection.Elevation of the lymphocycte count above 35% of the total white cell count has a specificity of 100% and a sensitivity of 90% for the detection of glandular fever.Normal to moderately elevated white blood cell count, particularly the number of lymphocytes is observed with a total white blood count increased to 10,000-20,000 per cubic millimeter.Antibodies to several antigen complexes may be measured, which include: early antigen, viral capsid antigen and epstein barr nuclear antigen. Epstein-Barr virus antibody titers to distinguish acute infection from past infection with EBV.Epstein-Barr virus antigen by immunofluorescence.It can also be used to test for atypical cases of mononucleosis or in young children who are suspected of having mononucleosis. Epstein-Barr virus specific antibody testing may be used for people with suspected mononucleosis who have heterophile antibody test results that are negative.Instead, serologic testing is the method of choice for diagnosing primary infection.Direct detection of EBV in blood or lymphoid tissues is a research tool and is not available for routine diagnosis.When mono spot or heterophile test results are negative, additional laboratory testing may be needed to differentiate EBV infections from a mononucleosis-like illness induced by cytomegalovirus, adenovirus, or toxoplasma gondii.False-positive results may be found in a small number of patients, and false-negative results may be obtained in 10% to 15% of patients, primarily in children younger than 10 years of age.Moderate-to-high levels of heterophile antibodies are seen during the first month of illness and decrease rapidly after week 4.In patients with symptoms compatible with infectious mononucleosis, a positive Paul-Bunnell heterophile antibody test result is diagnostic, and no further testing is necessary.A positive reaction to a mono spot test.

An increased total number of lymphocytes.

A normal to moderately elevated white blood cell count.

In most cases of infectious mononucleosis, the clinical diagnosis can be made from the characteristic triad of fever, pharyngitis, and lymphadenopathy lasting for 1 to 4 weeks. Risk calculators and risk factors for Mononucleosis laboratory findingsĮditor-In-Chief: C. Mononucleosis laboratory findings in the newsīlogs on Mononucleosis laboratory findingsĭirections to Hospitals Treating Mononucleosis Mononucleosis laboratory findings On the WebĪmerican Roentgen Ray Society Images of Mononucleosis laboratory findingsĪll Images X-rays Echo & Ultrasound CT Images MRI Natural History, Complications and Prognosis The Epstein-Barr virus causes infectious mononucleosis.Differentiating Mononucleosis from other Diseases Heterophile antibodies, in people with infectious mononucleosis, may be present as early as the fourth day of illness, and by the twenty-first day of illness, 90% of people will exhibit a positive test. Where can I find a Mononucleosis, Qualitative Test near me?Ĭheck our lab finder to locate a collection site in your area. Turnaround time for the Mononucleosis, Qualitative test is typically 1 - 3 business days. If the test results are negative but the symptoms persist, a doctor may recommend repeat testing after a week or so or follow up testing for Epstein Barr Virus. The antibodies which are detectable by a Mononucleosis test are typically present in 80% of cases. The Mononucleosis test is often ordered with a Complete Blood Count (CBC) for a more thorough analysis. This test is typically ordered when someone, especially a teen or young adult, is experiencing symptoms associated with Mono such as fever, headache, sore throat, swollen glands, fatigue, rash or stomach pain. Most cases resolve themselves without treatment. Symptoms usually develop within a month of the initial infection and persist for several weeks. Mononucleosis typically develops in adolescents or young people when they are first exposed to EBV. EBV is spread through the saliva and nearly 95% of people will be exposed by age 40. This test looks for Heterophile Antibodies which the immune system produces in response to an infection. Mononucleosis is an infection caused by Epstein Barr Virus (EBV). This test is used to aid in the diagnosis of Infectious Mononucleosis (Mono). Description: Mononucleosis Qualitative Blood Test

Mono blood test